Cell metabolism and Cancer associated fibroblasts
The CRUK Beatson Institute is a cancer research institute, situated in Glasgow with approximately 250 researchers split across 30 research groups consisting of PIs, postdoctoral scientists, PhD students and scientific officers. It is one of Europe's leading cancer research centres, supporting cutting-edge work into the molecular mechanisms of cancer development. As well as core support from Cancer Research UK, the Institute also receives an additional third of its total income from external grants and industry collaborations. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis. Its research ethos is about excellence, honesty, openness, accountability and integrity.
A postdoctoral position is available in the Tumour Microenvironment & Proteomics group headed by Professor Sara Zanivan. The group is a vibrant team, which aims to understand how cancer-associated fibroblasts (CAFs) influence tumour development and metastatic spread, with a focus on their metabolism. We are currently looking for a highly skilled and motivated postdoc to join our multidisciplinary team to study the roles of cell metabolism in regulating CAF functions important for metastatic dissemination in highly aggressive ovarian and breast cancers (Kay E. et al. Nature Metabolism, in press, https://www.biorxiv.org/content/10.1101/2020.05.30.125237v2.full).
This post will identify and functionally characterise metabolic pathways that control CAF functions important to support their tumour-promoting and immune-modulatory functions. The project involves analysis of our and publicly available omics datasets, heterotypic cell cultures with patient-derived cells, state-of-the-art omics technologies, including MS-based metabolomics and proteomics, and in vivo models.
This post will identify and functionally characterise metabolic pathways that control CAF functions important to create a tumour-promoting tumour and immune microenvironment. The project involves analysis of our and publicly available omics datasets, heterotypic cell cultures with patient-derived cells, state-of-the-art omics technologies, including metabolomics and proteomics, and in vivo models.
Applicants must have a PhD in a relevant field, be ambitious and driven by scientific curiosity. Previous experience with regard to cell metabolism is highly recommended, and experience or interest in CAFs, in vivo cancer models and omics data analysis would be an advantage.
To find out more about this unique opportunity to establish advanced skills and expertise in this exciting field please contact: Professor Sara Zanivan s.zanivan@beatson.gla.ac.uk
The Cancer Research UK Beatson Institute is committed to increase the number of female scientists at this level and encourages female applicants to apply. We have recently introduced a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children.
Closing date for applications is 15th July 2022.