Mitochondrial genetics, dysfunction and cancer
Would you like to develop your scientific career in a research institute that is founded on the quality of its people, acknowledged for its collaborative environment and designed to promote the development of the most outstanding and dedicated scientists. Many early career researchers have already made that decision and at present over 100 of them are now benefiting from our excellent training programme.
The Cancer Research UK Beatson Institute supports cutting edge research into the molecular mechanisms of cancer development and is one of the leading research institutes in Europe. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies, with special emphasis on imaging, metabolomics, and in vivo models.
Our innovative and ambitious research themes focus on understanding the regulation of the tumour microenvironment and cancer metabolism, in particular:
We currently have a vacancy for a Postdoctoral Scientist to explore the role of mitochondrial genetics in cancer-associated mitochondrial dysfunction.
Mitochondrial dysfunction is intimately linked with cancer initiation and progression and rewiring of mitochondrial metabolism can greatly benefit the cancer cell, fuelling proliferative and invasive cellular behaviours (Gaude et al., 2018). While mutations of the mitochondrial genome, with the potential to profoundly affect mitochondrial metabolism, are found in >50% of solid tumours, the contribution of mutated mtDNA to cancer initiation and progression is yet to be firmly established (Gammage et al., 2019).
To better understand the nature of mitochondrial dysfunction in cancer, through use and development of novel genetic tools (Gammage et al., 2018b) in cellular and animal models, we aim to untangle the role of mtDNA mutations in human cancer.
Applicants must have a PhD in a relevant field, be driven by scientific curiosity and have an excellent publication record in mitochondrial biology and/or cancer biology and metabolism. Experience with in vivo models of cancer and/or genome engineering techniques will be an advantage.
To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of mitochondrial oncogenetics please contact Dr Payam Gammage (payam.gammage@glasgow.ac.uk).
Gammage et al., 2018a, Trends in Genetics. 34: 101-110.
Gammage et al., 2018b, Nature Medicine. 24: 1691-1695.
Gammage et al., 2019, BMC Biology. 17: 53.
Gaude et al., 2018, Molecular Cell. 69: 581-593.
https://www.researchgate.net/profile/Payam_Gammage
At the Cancer Research UK Beatson Institute, we are committed to increasing the number of female scientists at this level and strongly encourage female applicants to apply. We have recently introduced a highly attractive, innovative maternity policy, which includes providing a postdoc with support and funding so that their projects can continue during their maternity leave.
Closing date for applications: 5th June 2020